A fruit fly’s wiring diagram has been hooked up to Doom. I didn’t run DoomFly itself, only the pieces under it, and the most useful thing in the project is the author’s own review. The full male CNS connectome (about 166,000 neurons) really does drive the controls: cut every edge and the control disappears. But the baseline model has fixed weights, its controls stay active when the screen is painted black, and the actions are read from four descending neurons with fixed gains. A newer experimental mode adds a plasticity rule on about 4,200 connections; the author reports that it still fails the visual, conditioning and survival checks.
So the honest sentence is the author’s: a full connectome, simulated with approximate dynamics, drives an engineered Doom interface. A character that moves is not a fly that understands the game.
The part underneath is better news than the headline. The male CNS data sits in a public bucket with no account needed, and a whole-brain run of the female FlyWire brain took 14 seconds on a CPU, compile included.